产品货号：
Z23768
中文名称：
PLEKHM1抗体
英文名称：
Anti-PLEKHM1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PLEKHM1 Antibody |
| 指标别名 | 162kDa adapter protein;AP162;B2;KIAA0356;OPTB6;PLEKHM1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | PLEKHM1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | PLEKHM1 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human PLEKHM1.The immunogen is located within amino acids 50 - 100 of PLEKHM1. |
| 计算分子量 | 117kDa |
| 成分 | PLEKHM1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | PLEKHM1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | PLEKHM1 is a member of the M family of Pleckstrin homolog domain-containing proteins,a group of proteins containing a RUN domain,two pleckstrin homology domains,and a cysteine-rich domain.It was identified through segregation analysis as a cause of osteopetrosis in humans.PLEKHM1 co-localizes with Rab7 to late endosomal/lysosomal vesicles in HEK293 and osteoclast-like cells,with this co-localization dependent on the prenylation of Rab7.Monocytes from a patient homozygous for a mutated form of PLEKHM1differentiated into osteoclasts normally,but failed to form ruffled borders and showed little evidence of bone resorbtion when cultured on dentine discs.Another mutation of PLEKHM1 impaired vesicular acidification and increased TRACP secretion in osteoclasts,suggesting that PLEKHM1 has critical roles in endosomal maturation and may be important in osteoclast-osteoblast cross-talk. |
| Uniprot ID | Q9Y4G2 |
| 基因名全称 | Pleckstrin homology domain containing,family M (with RUN domain) member 1 |
| 蛋白名全称 | Pleckstrin homology domain containing,family M (with RUN domain) member 1 |
| 推荐稀释比 | PLEKHM1 antibody can be used for detection of PLEKHM1 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
相关搜索：PLEKHM1抗体，PLEKHM1多抗，Anti-PLEKHM1 Antibody